Endocrine Abstracts

LHX3, a member of the LIM-homeodomain family of developmental transcription factors, is required for establishment of mammalian anterior pituitary hormone-secreting cell types as well as the formation of specialized neurons of the nervous system. Paediatric patients with pituitary insufficiency are sometimes diagnosed with combined pituitary hormone deficiency disease (CPHD). This disease can be linked to mutations in essential pituitary developmental transcription factor gene...

Radioactive iodine scanning and ablative radioactive therapy (RAI) are mainstays of follow-up and therapy in patients with differentiated thyroid carcinoma. TSH levels of 30 or greater are recommended as the levels required for effective use of RAI (see recent British Thyroid Association guidelines).To clarify our own practice we have studied 20 consecutive patients undergoing ablative RAI for thyroid carcinoma (10 papillary, 8 follicular and 2 mixed). The fourteen who had...